A new technique for delivering a polyglycolic acid sheet to cover a large mucosal defect: the Swiss roll method.

Endoscopic tissue shielding with polyglycolic acid (PGA) sheets (Neoveil; Gunze Co., Kyoto, Japan) and fibrin glue (Beriplast P CombiSet; CSL Behring Pharma, Tokyo, Japan) is a promising method for preventing postoperative complications [1–3]. However, this technique is thought to be inefficient for covering large mucosal defects because it takes time to deliver many small PGA sheets. Accordingly, we devised and implemented a new technique involving the delivery of a single large PGA sheet. A 25-year-old woman with familial adenomatous polyposis was treated using a standard-caliber endoscope by rectal piecemeal endoscopic mucosal resection, leaving a large mucosal defect (●" Fig.1). For our new technique, we used a PGA sheet and its accompanying plastic packaging sheet.We cut the PGA sheet to cover the artificial ulcer, and then we cut the plastic sheet to a slightly smaller size. We attached one edge of the plastic sheet to a small-caliber endoscope with tape. Next, we placed the PGA sheet over the plastic sheet, and we proceeded to roll the two layers around the small-caliber endoscope like a Swiss roll, making sure the PGA sheet was on the outside. We placed the enwrapped small-caliber endoscope inside an overtube (Flexible Overtube; Sumitomo Bakelite Inc., Tokyo, Japan) to prevent contact with any moisture. We delivered the second endoscope within the overtube to the ulcer and then removed the overtube. Using the biopsy forceps of the standard-caliber endoscope, we grasped one end of the PGA sheet (●" Fig.2 a) and fixed it to one edge of the ulcer with clips (●" Fig.2b). We proceeded to unroll the PGA sheet over the ulcer (●" Fig.2c). The plastic sheet underneath gradually separated from the PGA sheet and remained curled around the small-caliber endoscope. We then fixed the PGA sheet using several clips (●" Fig.2d). This technique can be used to achieve the delivery of a single large PGA sheet to cover a sizeable mucosal defect.